GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2275426 | 1 | rs6662641 | chr1:46571509 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -9.9 | 3.88E-21 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6662641 | chr1:46571509 | GPBP1L1 | chr1:46092978-46152302:- | 0.15 | 3.73 | 0.000214 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6662641 | chr1:46571509 | MMACHC | chr1:45965856-45976737:+ | -0.21 | -4.53 | 7.42E-6 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6662641 | chr1:46571509 | MUTYH | chr1:45794915-45806142:- | 0.29 | 7.65 | 1.12E-13 | Body mass index |
| THCA | cis | rs7742824 | 1 | rs66629131 | chr6:44101468 | TMEM63B | chr6:44095376-44123255:+ | 0.16 | 3.55 | 0.000427 | Major depressive disorder |
| THCA | cis | rs6686842 | 1 | rs6663565 | chr1:41563688 | SCMH1 | chr1:41492875-41707788:- | 0.2 | 4.7 | 3.36E-6 | Height |
| THCA | cis | rs7551345 | 1 | rs6663779 | chr1:31835527 | ZCCHC17 | chr1:31769842-31837780:+ | -0.3 | -5.61 | 3.38E-8 | Schizophrenia |
| THCA | cis | rs7968440 | 1 | rs66644594 | chr12:50932983 | DIP2B | chr12:50898768-51142448:+ | 0.12 | 3.82 | 0.000151 | Fibrinogen |
| THCA | cis | rs12579753 | 1 | rs66646148 | chr12:82248520 | PPFIA2 | chr12:81652880-82153109:- | 0.22 | 4.13 | 4.25E-5 | Resting heart rate |
| THCA | cis | rs9662633 | 1 | rs6664760 | chr1:3648268 | KIAA0495 | chr1:3652550-3663886:- | 0.27 | 3.67 | 0.000272 | Visceral adipose tissue adjusted for BMI |
| THCA | cis | rs891378 | 1 | rs6664815 | chr1:207415563 | CD55 | chr1:207494817-207534309:+ | 0.14 | 6.46 | 2.66E-10 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs1411478 | 1 | rs6665134 | chr1:180949628 | MR1 | chr1:181003139-181024633:+ | -0.12 | -3.42 | 0.00068 | Progressive supranuclear palsy |
| THCA | cis | rs1411478 | 1 | rs6665134 | chr1:180949628 | STX6 | chr1:180913175-180992046:- | -0.2 | -4.08 | 5.32E-5 | Progressive supranuclear palsy |
| THCA | cis | rs748404 | 1 | rs66651343 | chr15:43558004 | STRC | chr15:43891762-43924561:- | 0.28 | 5.87 | 8.01E-9 | Lung cancer |
| THCA | cis | rs7551345 | 1 | rs6665949 | chr1:31862537 | ZCCHC17 | chr1:31769842-31837780:+ | -0.3 | -5.66 | 2.61E-8 | Schizophrenia |